Laboratory of Polypeptide Drugs and Delivery

Dr Peter Moyle (@moylelab) - the University of Queensland School of Pharmacy

Australian Research Council (ARC) Grant Success

We thank the Australian Research Council (ARC) and the Australian Government for awarding our laboratory and collaborators (Prof Toth, UQ) with a 2020 ARC Discovery Project Grant for 3 years.

link: Funding Announcement

We look forward to the research and training opportunities that this funding will provide.

Project Summary: Developing a multicomponent platform for targeted gene delivery. Gene delivery systems are important tools in biological research and offer many exciting future prospects. Delivering gene material is very difficult in practice: rapid deterioration, poor cell uptake, and reaching the right tissue and cell types are major obstacles. Ways to overcome each barrier individually have been suggested in existing research but these components have not yet been combined in a single solution, which this project will tackle. This proposal aims to create a technology to stabilise and deliver active gene material to target cells. The gene delivery tool developed in this project will advance biological research greatly with many potential future applications.

Congratulations to Zhenghui Xu on Your Journal of Controlled Release Article

Congratulations to PhD student Zhenghui Xu on the submission of your thesis and the publication of your 1st research article in the prestigious Journal of Controlled Release.

His publication describes a simple, efficient Sortase A enzyme-mediated means to site-specifically conjugate Toll-like receptor 2 agonist lipopeptide adjuvants onto recombinant protein antigens.

This work generates highly defined, self-adjuvanting vaccines, and unlike the recombinant processes used for the production of other lipoprotein vaccines like Trumenba, it ensures that a single type of fatty acid is incorporated into the lipopeptide portion, rather than a heterogeneous mixture.

The paper demonstrates the use of this system for developing broadly protective vaccines against group A streptococcus (GAS), which is responsible for diseases ranging from a sore throat through to heart valve and kidney damage, and the flesh eating disease necrotising fasciitis.

Xu Z, Rivera-Hernandez T, Chatterjee O, Walker MJ, Moyle PM. Semisynthetic, self-adjuvanting vaccine development: Efficient, site-specific sortase A-mediated conjugation of Toll-like receptor 2 ligand FSL-1 to recombinant protein antigens under native conditions and application to a model group A streptococcal vaccine. J Control Release 2020;317:96-108

(https://doi.org/10.1016/j.jconrel.2019.11.018)

Congratulations to Faheem Maqbool on New Publication

Congratulations to PhD student Faheem Maqbool. His new publication on how supercritical carbon dioxide can be used to efficiently produce and load liposomes with drugs has been published online in Artificial Cells, Nanomedicine, and Biotechnology.

Maqbool F, Moyle PM, Tan MSA, Thurecht KJ, Falconer JR. Preparation of albendazole-loaded liposomes by supercritical carbon dioxide processing. Art Cells Nanomed Biotechnol 2018; in press

(https://doi.org/10.1080/21691401.2018.1536059)

Congratulations Zhenghui Xu on your article in Bioconjugate Chemistry

Congratulations to PhD student Zhenghui Xu on the acceptance and publication of his review ‘bioconjugation approaches to produce subunit vaccines composed of protein or peptide antigens and covalently attached toll-like receptor ligands‘ in the ACS journal Bioconjugate Chemistry.

 

Acta Biomaterialia – Targeted siRNA/pDNA delivery systems

Congratulations to Dr Yu Wan on the acceptance and publication of her article ‘multifunctional peptide-lipid nanocomplexes for efficient targeted delivery of DNA and siRNA into breast cancer cells’ in Acta Biomaterialia

DOI: 10.1016/j.actbio.2017.06.032

Congratulations Yu Wan

Congratulations to Dr Yu Wan, who has successfully completed her requirements to be awarded a Doctor of Philosophy (PhD) from the University of Queensland on the 7th of July 2017.

Best wishes for your future career endeavours.

 

Article Accepted in Biotechnology Advances

Read our new article on “biotechnology approaches to produce potent, self-adjuvanting antigen-adjuvant fusion protein subunit vaccines” in Biotechnology Advances (IF 9.848).

DOI: 10.1016/j.biotechadv.2017.03.005

Biotage Initiator+ Alstra Peptide Synthesiser

We have recently received a Biotage Initiator+ Alstra automated microwave peptide synthesiser, which will provide rapid, safe, and high quality peptides for student projects in the school of pharmacy courtesy of the UQ Major Equipment Infrastructure grants.

Feel free to contact us if you are interested in using this instrument.

Globalisation of Pharmaceutics Education Network (GPEN) 2016

Currently at the Globalization of Pharmaceutics Education Network (GPEN) 2016 conference in Lawrence, Kansas USA

Congratulations to 2016 major students

Congratulations to Eloise Lloyd, James Stephanie, Joey Cheng and Merhawi Asfha for  completing their Major project assessments.

 

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